What Is Positive Cologuard? Next Steps Explained

Positive Cologuard results can be a cause for concern, but it's essential to understand what this test detects and the next steps to take. Cologuard is a non-invasive, stool-based DNA test designed to detect colorectal cancer and pre-cancerous lesions in individuals 45 years and older. The test analyzes stool samples for DNA mutations and blood hemoglobin, which can indicate the presence of cancer or pre-cancerous cells in the colon.
Understanding Positive Cologuard Results

A positive Cologuard result indicates that the test has detected one or more of the following: abnormal DNA mutations, blood in the stool, or other biomarkers associated with colorectal cancer. However, a positive result does not necessarily mean that you have colorectal cancer. It’s crucial to follow up with a healthcare provider to determine the next course of action. According to the Centers for Disease Control and Prevention (CDC), approximately 1 in 10 Cologuard tests will return a positive result, but most of these will not be due to cancer.
Next Steps After a Positive Cologuard Result
If you receive a positive Cologuard result, your healthcare provider will likely recommend a colonoscopy to further investigate the findings. A colonoscopy is a procedure that allows a doctor to visually examine the inside of the colon using a flexible tube with a camera and light on the end. This test can help identify the source of the abnormal result, which may include polyps, inflammatory bowel disease, or other conditions. In some cases, a CT colonography or other imaging tests may be recommended instead.
Test | Description |
---|---|
Colonoscopy | A procedure that allows a doctor to visually examine the inside of the colon |
CT Colonography | An imaging test that uses X-rays and computer technology to produce images of the colon |

Preparation for Follow-Up Tests

Before undergoing a colonoscopy or other follow-up tests, it’s essential to prepare properly. Your healthcare provider will provide specific instructions, which may include dietary restrictions, bowel preparation, and medication adjustments. It’s crucial to follow these instructions carefully to ensure accurate test results. Additionally, you may want to ask your healthcare provider about the risks and benefits associated with the follow-up tests, as well as any potential alternatives or additional testing that may be necessary.
Understanding the Risks and Benefits of Follow-Up Tests
While follow-up tests are essential for determining the cause of a positive Cologuard result, they also carry some risks and benefits. For example, a colonoscopy is generally a safe procedure, but it can cause bleeding, infection, or perforation of the colon in rare cases. On the other hand, a colonoscopy can also help prevent colorectal cancer by allowing doctors to remove pre-cancerous polyps. It’s essential to discuss these risks and benefits with your healthcare provider to make informed decisions about your care.
- Risks associated with colonoscopy: bleeding, infection, perforation of the colon
- Benefits associated with colonoscopy: removal of pre-cancerous polyps, prevention of colorectal cancer
What does a positive Cologuard result mean?
+A positive Cologuard result indicates that the test has detected abnormal DNA mutations, blood in the stool, or other biomarkers associated with colorectal cancer. However, it does not necessarily mean that you have colorectal cancer.
What are the next steps after a positive Cologuard result?
+Your healthcare provider will likely recommend a colonoscopy to further investigate the findings. A colonoscopy is a procedure that allows a doctor to visually examine the inside of the colon using a flexible tube with a camera and light on the end.
How do I prepare for a colonoscopy?
+Your healthcare provider will provide specific instructions, which may include dietary restrictions, bowel preparation, and medication adjustments. It’s crucial to follow these instructions carefully to ensure accurate test results.
What are the risks and benefits associated with follow-up tests?
+While follow-up tests are essential for determining the cause of a positive Cologuard result, they also carry some risks and benefits. For example, a colonoscopy is generally a safe procedure, but it can cause bleeding, infection, or perforation of the colon in rare cases. On the other hand, a colonoscopy can also help prevent colorectal cancer by allowing doctors to remove pre-cancerous polyps.
What are the alternatives to a colonoscopy?
+Alternatives to a colonoscopy may include a CT colonography or other imaging tests. However, these alternatives may not be suitable for everyone, and your healthcare provider will discuss the best options for your individual situation.